2011
- Baliga SS, Merrill GF, Shinohara ML,
Denhardt DT.
Osteopontin
Expression during Early Cerebral Ischemia-Reperfusion in Rats: Enhanced
Expression in the Right Cortex Is Suppressed by Acetaminophen.
PLoS One. 2011 Jan 21;6(1):e14568
- Wang KX, Shi YF, Ron Y, Kazanecki CC,
Denhardt DT. Plasma osteopontin modulates chronic restraint stress-induced
thymus atrophy by regulating stress hormones: inhibition by an anti-osteopontin
monoclonal antibody. J Immunol. 2009 182:2485-91.
- Wang KX, Denhardt DT. Osteopontin: role
in immune regulation and stress responses. Cytokine Growth Factor
Rev. 2008 19:333-45.
- Other publications that my name pulls
up on PubMed are the recent results of collaborations with other laboratories,
notably Drs. Hwyda Arafat, Masaki Noda, Esben Sorensen, Larry Steinman,
and Toshi Uede.
2010
- Haders DJ, Kazanecki CC, Denhardt DT, Riman RE. Crystallographically
engineered, hydrothermally crystallized hydroxyapatite films: an in
vitro study of bioactivity. J Mater Sci Mater Med. 2010 21:1531-42.
2009 (incomplete)
- Fujita N, Fujita S, Okada Y, Fujita K, Kitano A, Yamanaka O, Miyamoto
T, Kon S, Uede T, Rittling SR, Denhardt DT, Saika S. (20009) Impaired
angiogenic response in the cornea of mice lacking osteopontin. Invest
Ophthalmol Vis Sci. Sep 9. [Epub ahead of print] PubMed PMID: 19741245.
- Matsui Y, Iwasaki N, Kon S, Takahashi D, Morimoto J, Matsui Y, Denhardt
DT, Rittling S, Minami A, Uede T. (2009) Accelerated development of
aging-associated and instability-induced osteoarthritis in osteopontin-deficient
mice. Arthritis Rheum. 60:2362-71.
- Sullivan J, Blair L, Alnajar A, Aziz T, Ng CY, Chipitsyna G, Gong
Q, Witkiewicz A, Weber GF, Denhardt DT, Yeo CJ, Arafat HA. (2009)
Expression of a prometastatic splice variant of osteopontin, OPNC,
in human pancreatic ductal adenocarcinoma. Surgery. 146:232-40.
- Grassinger J, Haylock DN, Storan MJ, Haines GO, Williams B, Whitty
GA, Vinson AR, Be CL, Li S, Sørensen ES, Tam PP, Denhardt DT,
Sheppard D, Choong PF, Nilsson SK. (2009) Thrombin-cleaved osteopontin
regulates hemopoietic stem and progenitor cell functions through interactions
with alpha9beta1 and alpha4beta1 integrins. Blood. 114:49-59.
- Chipitsyna G, Gong Q, Anandanadesan R, Alnajar A, Batra SK, Wittel
UA, Cullen DM, Akhter MP, Denhardt DT, Yeo CJ, Arafat HA. (2009) Induction
of osteopontin expression by nicotine and cigarette smoke in the pancreas
and pancreatic ductal adenocarcinoma cells. Int J Cancer. 125:276-85.
- Maeno Y, Shinzato M, Nagashima S, Rittling SR, Denhardt DT, Uede
T, Taniguchi K. (2009) Effect of osteopontin on diarrhea duration
and innate immunity in suckling mice infected with a murine rotavirus.
Viral Immunol. 22:139-44.
- Wang KX, Shi YF, Ron Y, Kazanecki CC, Denhardt DT. (2009) Plasma
osteopontin modulates chronic restraint stress-induced thymus atrophy
by regulating stress hormones: inhibition by an anti-osteopontin monoclonal
antibody. J Immunol. 182:2485-91.
2008
-
Diao H, Iwabuchi K, Li
L, Onoe K, Van Kaer L, Kon S, Saito Y, Morimoto J, Denhardt DT,
Rittling S, Uede T. (2008) Osteopontin regulates development and
function of invariant natural killer T cells. Proc Natl Acad Sci
U S A. 105:15884-9.
-
Sato I, Yamamoto N, Rittling
SR, Denhardt DT, Hino M, Morimoro J, Sakai F, Fujie A, Uede T. (2008)
Osteopontin is dispensable for protection against high load systemic
fungal infection. Int Immunopharmacol. 8:1441-8.
- Borges K, Gearing M, Rittling S, Sorensen ES, Kotloski R, Denhardt
DT, Dingledine R. (2008) Characterization of osteopontin expression
and function after status epilepticus. Epilepsia. 49:1675-85.
- Ono N, Nakashima K, Rittling SR, Schipani E, Hayata T, Soma K, Denhardt
DT, Kronenberg HM, Ezura Y, Noda M. (2008) Osteopontin negatively
regulates parathyroid hormone receptor signaling in osteoblasts. J
Biol Chem. 283:19400-9.
- Miyazaki K, Okada Y, Yamanaka O, Kitano A, Ikeda K, Kon S, Uede
T, Rittling SR, Denhardt DT, Kao WW, Saika S. (2008) Corneal wound
healing in an osteopontin-deficient mouse. Invest Ophthalmol Vis Sci.
49:1367-75.
- Chung CJ, Soma K, Rittling SR, Denhardt DT, Hayata T, Nakashima
K, Ezura Y, Noda M. (2008) OPN deficiency suppresses appearance of
odontoclastic cells and resorption of the tooth root induced by experimental
force application. J Cell Physiol. 214:614-20.
2007
-
Kazanecki CC, Kowalski AJ, Ding T, Rittling SR,
Denhardt DT. (2007) Characterization of anti-osteopontin monoclonal
antibodies: Binding sensitivity to post-translational modifications.
J Cell Biochem. 102:925-35.
-
Wang KX, Shi Y, Denhardt DT. (2007) Osteopontin
regulates hindlimb-unloading-induced lymphoid organ atrophy and
weight loss by modulating corticosteroid production. Proc Natl Acad
Sci U S A. 104:14777-82.
-
Christensen B, Kazanecki CC, Petersen TE, Rittling
SR, Denhardt DT, Sørensen ES. (2007) Cell type-specific post-translational
modifications of mouse osteopontin are associated with different
adhesive properties. J Biol Chem. 282:19463-72.
-
Kitamura M, Iwabuchi K, Kitaichi N, Kon S, Kitamei
H, Namba K, Yoshida K, Denhardt DT, Rittling SR, Ohno S, Uede T,
Onoé K. (2007) Osteopontin aggravates experimental autoimmune uveoretinitis
in mice. J Immunol. 178:6567-72.
-
Hashimoto M, Sun D, Rittling SR, Denhardt DT,
Young W. (2007) Osteopontin-deficient mice exhibit less inflammation,
greater tissue damage, and impaired locomotor recovery from spinal
cord injury compared with wild-type controls. J Neurosci. 27:3603-11.
-
Kavukcuoglu NB, Denhardt DT, Guzelsu N, Mann
AB. (2007) Osteopontin deficiency and aging on nanomechanics of
mouse bone. J Biomed Mater Res A. 83:136-44.
-
Wung JK, Perry G, Kowalski A, Harris PL, Bishop
GM, Trivedi MA, Johnson SC, Smith MA, Denhardt DT, Atwood CS. (2007)
Increased expression of the remodeling- and tumorigenic-associated
factor osteopontin in pyramidal neurons of the Alzheimer's disease
brain. Curr Alzheimer Res. 4:67-72.
-
Marsh BC, Kerr NC, Isles N, Denhardt DT, Wynick
D. (2007) Osteopontin expression and function within the dorsal
root ganglion. Neuroreport. 18:153-7.
-
Saika S, Shirai K, Yamanaka O, Miyazaki K, Okada
Y, Kitano A, Flanders KC, Kon S, Uede T, Kao WW, Rittling SR, Denhardt
DT, Ohnishi Y. (2007) Loss of osteopontin perturbs the epithelial-mesenchymal
transition in an injured mouse lens epithelium. Lab Invest. 87:130-8.
-
Mori N, Majima T, Iwasaki N, Kon S, Miyakawa
K, Kimura C, Tanaka K, Denhardt DT, Rittling S, Minami A, Uede T.
(2007) The role of osteopontin in tendon tissue remodeling after
denervation-induced mechanical stress deprivation. Matrix Biol.
26:42-53.
-
Hayashi C, Rittling S, Hayata T, Amagasa T, Denhardt
D, Ezura Y, Nakashima K, Noda M. (2007) Serum osteopontin, an enhancer
of tumor metastasis to bone, promotes B16 melanoma cell migration.
J Cell Biochem. 101:979-86.
-
Kato N, Kitahara K, Rittling SR, Nakashima K,
Denhardt DT, Kurosawa H, Ezura Y, Noda M. (2007) Osteopontin deficiency
enhances anabolic action of EP4 agonist at a sub-optimal dose in
bone. J Endocrinol. 193:171-82.
-
Ishijima M, Tsuji K, Rittling SR, Yamashita T,
Kurosawa H, Denhardt DT, Nifuji A, Ezura Y, Noda M. (2007) Osteopontin
is required for mechanical stress-dependent signals to bone marrow
cells. J Endocrinol. 193:235-43.
2006
-
Da Silva AP, Pollett A, Rittling SR, Denhardt DT, Sodek J, Zohar
R. (2006)Exacerbated tissue destruction in DSS-induced acute colitis
of OPN-null mice is associated with downregulation of TNF-alpha
expression and non-programmed cell death. J Cell Physiol. 208:629-39.
-
Ishijima M, Ezura Y, Tsuji K, Rittling SR, Kurosawa H, Denhardt
DT, Emi M, Nifuji A, Noda M. (2006) Osteopontin is associated with
nuclear factor kappaB gene expression during tail-suspension-induced
bone loss. Exp Cell Res. 312:3075-83.
-
Lai CF, Seshadri V, Huang K, Shao JS, Cai J, Vattikuti R, Schumacher
A, Loewy AP, Denhardt DT, Rittling SR, Towler DA. (2006)An osteopontin-NADPH
oxidase signaling cascade promotes pro-matrix metalloproteinase
9 activation in aortic mesenchymal cells. Circ Res. 98:1479-89.
-
Schroeter M, Zickler P, Denhardt DT, Hartung HP, Jander S. (2006)
Increased thalamic neurodegeneration following ischaemic cortical
stroke in osteopontin-deficient mice. Brain. 129:1426-37.
-
Maeno Y, Nakazawa S, Yamamoto N, Shinzato M, Nagashima S, Tanaka
K, Sasaki J, Rittling SR, Denhardt DT, Uede T, Taniguchi K. (2006)
Osteopontin participates in Th1-mediated host resistance against
nonlethal malaria parasite Plasmodium chabaudi chabaudi infection
in mice. Infect Immun. 74:2423-7.
-
Koyama Y, Rittling SR, Tsuji K, Hino K, Salincarnboriboon R, Yano
T, Taketani Y, Nifuji A, Denhardt DT, Noda M. (2006)Osteopontin
deficiency suppresses high phosphate load-induced bone loss via
specific modulation of osteoclasts.
Endocrinology 147:3040-9
2005
-
Porter JF, Sharma S, Wilson DL, Kappil MA, Hart RP, Denhardt DT.
(2005) Tissue Inhibitor of Metalloproteinases-1 Stimulates Gene
Expression in MDA-MB-435 Human Breast Cancer Cells by Means of its
Ability to Inhibit Metalloproteinases. Breast Cancer Res Treat.
94:185-93.
-
Vernon HJ, Osborne C, Tzortzaki EG, Yang M, Chen J, Rittling SR,
Denhardt DT, Buyske S, Bledsoe SB, Evan AP, Fairbanks L, Simmonds
HA, Tischfield JA, Sahota A. (2005) Aprt/Opn double knockout mice:
osteopontin is a modifier of kidney stone disease severity. Kidney
Int. 68:938-47.
- Zhu Y, Denhardt DT, Cao H, Sutphin PD, Koong AC, Giaccia AJ, Le
QT. (2005)Hypoxia upregulates osteopontin expression in NIH-3T3 cells
via a Ras-activated enhancer. Oncogene. 24:6555-63.
- Kondo H, Nifuji A, Takeda S, Ezura Y, Rittling SR, Denhardt DT,
Nakashima K, Karsenty G, Noda M. (2005) Unloading induces osteoblastic
cell suppression and osteoclastic cell activation to lead to bone
loss via sympathetic nervous system. J Biol Chem. 280:30192-200.
- Nilsson SK, Johnston HM, Whitty GA, Williams B, Webb RJ, Denhardt
DT, Bertoncello I, Bendall LJ, Simmons PJ, Haylock DN. (2005) Osteopontin,
a key component of the hematopoietic stem cell niche and regulator
of primitive hematopoietic progenitor cells. Blood. 106:1232-9.
- Contractor T, Babiarz B, Kowalski AJ, Rittling SR, Sorensen ES,
Denhardt DT. (2005) Osteoclasts resorb protein-free mineral (Osteologic
discs) efficiently in the absence of osteopontin. In Vivo. 19:335-41.
- Rollo EE, Hempson SJ, Bansal A, Tsao E, Habib I, Rittling SR, Denhardt
DT, Mackow ER, Shaw RD. (2005) The cytokine osteopontin modulates
the severity of rotavirus diarrhea. J Virol. 79:3509-16.
- Denhardt D. (2005) Osteopontin expression correlates with melanoma
invasion. J Invest Dermatol. 2005 May;124(5):xvi-xviii.
- Khan SA, Cook AC, Kappil M, Günthert U, Chambers AF, Tuck AB, Denhardt
DT (2006) Enhanced cell surface CD44 variant (v6, v9) expression by
osteopontin in breast cancer epithelial cells facilitates tumor cell
migration: Novel post-transcriptional, post-translational regulation.
Clin. Expt. Metastasis (in press).
2004
-
Denhardt DT. (2004) The third international conference
on osteopontin and related proteins, San Antonio, Texas, May 10-12,
2002.Calcif Tissue Int. 74:213-9.
-
Diao H, Kon S, Iwabuchi K, Kimura C, Morimoto J, Ito
D, Segawa T, Maeda M, Hamuro J, Nakayama T, Taniguchi M, Yagita
H, Van Kaer L, Onoe K, Denhardt D, Rittling S, Uede T. (2004) Osteopontin
as a mediator of NKT cell function in T cell-mediated liver diseases.
Immunity. 21:539-50.
-
Matsui Y, Jia N, Okamoto H, Kon S, Onozuka H, Akino
M, Liu L, Morimoto J, Rittling SR, Denhardt D, Kitabatake A, Uede
T. (2004) Role of osteopontin in cardiac fibrosis and remodeling
in angiotensin II-induced cardiac hypertrophy. Hypertension 43:1195-201.
-
Morimoto J, Inobe M, Kimura C, Kon S, Diao H, Aoki M,
Miyazaki T, Denhardt DT, Rittling S, Uede T. (2004) Osteopontin
affects the persistence of beta-glucan-induced hepatic granuloma
formation and tissue injury through two distinct mechanisms. Int
Immunol. 16:477-88.
-
Ohyama Y, Nemoto H, Rittling S, Tsuji K, Amagasa T,
Denhardt DT, Nifuji A, Noda M. (2004) Osteopontin-deficiency suppresses
growth of B16 melanoma cells implanted in bone and osteoclastogenesis
in co-cultures. J Bone Miner Res. 19:1706-11.
-
Weintraub AS, Lin X, Itskovich VV, Aguinaldo JG, Chaplin
WF, Denhardt DT, Fayad ZA. (2004) Prenatal detection of embryo resorption
in osteopontin-deficient mice using serial noninvasive magnetic
resonance microscopy. Pediatr Res. 55:419-24.
-
Zhu B, Suzuki K, Goldberg HA, Rittling SR, Denhardt
DT, McCulloch CA, Sodek J. (2004) Osteopontin modulates CD44-dependent
chemotaxis of peritoneal macrophages through G-protein-coupled receptors:
evidence of a role for an intracellular form of osteopontin. J Cell
Physiol. 198:155-67.
2003
-
Wong YF, Selvanayagam ZE, Wei N, Porter J, Vittal R,
Hu R, Lin Y, Liao J,Shih JW, Cheung TH, Lo KW, Yim SF, Yip SK, Ngong
DT, Siu N, Chan LK, Chan CS, Kong T, Kutlina E, McKinnon RD, Denhardt
DT, Chin KV, Chung TK. (2003) Expression genomics of cervical cancer:
molecular classification and prediction of radiotherapy response
by DNA microarray. Clin Cancer Res. 9:5486-92
-
Shapses SA, Cifuentes M, Spevak L, Chowdhury H, Brittingham
J, Boskey AL, Denhardt DT. (2003) Osteopontin facilitates bone resorption,
decreasing bone mineral crystallinity and content during calcium
deficiency. Calcif Tissue Int. 73:86-92.
-
Morinobu M, Ishijima M, Rittling SR, Tsuji K, Yamamoto
H, Nifuji A, Denhardt DT, Noda M. (2003) Osteopontin expression
in osteoblasts and osteocytes during bone formation under mechanical
stress in the calvarial suture in vivo. J Bone Miner Res. 18:1706-15.
-
Hampel DJ, Sansome C, Romanov VI, Kowalski AJ, Denhardt
DT, Goligorsky MS. (2003) Osteopontin traffic in hypoxic renal epithelial
cells. Nephron Exp Nephrol. 94:66-76.
-
Chellaiah MA, Biswas RS, Rittling SR, Denhardt DT, Hruska
KA. (2003) Rho-dependent Rho kinase activation increases CD44 surface
expression and bone resorption in osteoclasts. J Biol Chem. 278:29086-97.
-
Matsui Y, Rittling SR, Okamoto H, Inobe M, Jia N, Shimizu
T, Akino M, Sugawara T, Morimoto J, Kimura C, Kon S, Denhardt D,
Kitabatake A, Uede T. (2003) Osteopontin deficiency attenuates atherosclerosis
in female apolipoprotein E-deficient mice. Arterioscler Thromb Vasc
Biol. 23:1029-34.
-
Kitahara K, Ishijima M, Rittling SR, Tsuji K, Kurosawa
H, Nifuji A, Denhardt DT, Noda M. (2003) Osteopontin deficiency
induces parathyroid hormone enhancement of cortical bone formation.
Endocrinology 144:2132-40.
-
Denhardt DT, Mistretta D, Chambers AF, Krishna S, Porter
JF, Raghuram S, Rittling SR. (2003) Transcriptional regulation of
osteopontin and the metastatic phenotype: evidence for a Ras-activated
enhancer in the human OPN promoter. Clin Exp Metastasis. 20:77-84.
-
Chellaiah MA, Kizer N, Biswas R, Alvarez U, Strauss-Schoenberger
J, Rifas L, Rittling SR, Denhardt DT, Hruska KA. (2003) Osteopontin
deficiency produces osteoclast dysfunction due to reduced CD44 surface
expression. Mol Biol Cell. 14:173-89.
2002
-
Chabas, D.,Baranzini, S.E., Mitchell, D., Bernard, C.C.A.,
Rittling, S.R., Denhardt, D.T., Sobel, R.A., Lock, C. Karpuj, M,
Pedotti, R., Heller, R. Oksenberg, J.R., and Steinman, L. (2001)
Osteopontin Influences The Transition from Relapsing / Remitting
to Progressive Autoimmune Demyelinating Disease. Science294:1731-1735.
-
Potter, M.R., Rittling, S.R., Denhardt, D.T., Roper,
R.J., Weis, J.J., Teuscher, C., and Weis, J.J. (2001) Role of osteopontin
in murine lyme arthritis or host defense against Borrelia burgdorferi.
Infection Immunity 70:1372-1381.
-
Noda, M., and Denhardt, D. T. (2002) Osteopontin. In
Principles of Bone Biology, 2nd ed. vol 1, 239-250. Academic Press.
-
Ishijima, M, Tsuji, K, Rittling, SR, Yamashita, T, Kurosawa,
H, Denhardt, DT, Nifuji, A, Noda M. (2002) Resistance to unloading-induced
three-dimensional bone loss in osteopontin-deficient mice. J Bone
Mineral Res. 4:661-7.
-
D’Alonzo, R.C., Kowalski, A. J., Denhardt, D. T., Nickols,
G. A., and Partridge, N. C. (2002) Regulation of collagenase-3 and
osteocalcin gene expression by collagen and osteopontin in differentiating
MC3T3-E1 cells. J. Biol. Chem. 277: 24788-24798.
-
Yumoto, K., Ishijima, M., Rittling, S.R., Tsuji, K.,
Tsuchiya, Y., Kon, S., Nifuji, A., Uede, T. Denhardt, D.T., and
Noda, M. (2002) Ostopontin deficiency protects joints against destruction
in anti-type II collagen antibody-induced arthritis in mice. Proc.
Natl. Acad. Sci. USA 99:4556-4561.
-
Khan, S., Lopez, C.A., Zhang, J., Sørensen, E., and
Denhardt, D.T. (2002) Soluble osteopontin inhibits apoptosis of
adherent endothelial cells deprived of growth factors. J. Cellular
Biochemistry 85:728-736.
-
Suzuki, K., Zhu, B., Rittling, S.R.,
Denhardt, D.T., Goldberg, H.A., McCulloch, C.A., Sodek, J. (2002)
Colocalization of intracellular osteopontin with CD44 is associated
with migration, cell fusion,
and resorption in osteoclasts. J Bone Miner Res 17:1486-1497.
2001
- Asou, Y., Rittling, S.R., Yoshitake, H., Tsuji, K.,
Shinomiya, K., Nifuji, A., Denhardt, D.T., and Noda, M. (2001) Osteopontin
facilitates angiogenesis, accumulation of osteoclasts, and resorption
of ectopic bone. Endocrinology 142:1325-1332.
- Attur, M.G., Dave, M.N., Stuchin, S., Kowalski, A.S.,
Steiner, G., Abramson, S.B., Denhardt, D.T., and Amin, A.R. (2001)
Osteopontin: An intrinsic inhibitor of inflammation in cartilage.
Arthritis and Rheumatism 44:578-584.
- Ishijimi, M., Rittling, S.R., Yamashita, T., Tsuji,
K., Kurosawa, H., Nifuji, A., Denhardt, D.T., and Noda, M. (2001)
Enhancement of osteoclastic bone resorption and suppression of osteoblastic
bone formation in response to reduced mechanical stress do not occur
in the absence of osteopontin. J. Exp. Med. 193:399-404.
- Denhardt, D.T., Noda, M., O’Regan, A.E., Pavlin, D., and Berman,
J.S. (2001) Osteopontin- a means to cope with environmental insults:
Regulation of inflammation, tissue remodeling and cell survival. J.
Clin. Invest. 107:1055-1061.
- Nemoto, H., Rittling, S.R., Yoshitake, H., Furuya,
K., Amagasa, T., Tsuji, K., Nifuji, A., Denhardt, D.T., Noda, M. (2001)
Osteopontin deficiency reduces experimental tumor cell metastasis
to bone and soft tissues. J. Bone Mineral Res. 16:652-659.
- Denhardt, D.T., Giachelli, C.M., Rittling, S.R. (2001)
Role of osteopontin in cellular signaling and toxicant injury. Annu.
Rev. Pharmacol. Toxicol.41:721-749.
- Ihara H, Denhardt DT, Furuya K, Yamashita T, Muguruma
Y, Tsuji K, Hruska KA, Higashiomoto S, Nifuji A, Rittling SR, Noda
M. (2001) Parathyroid hormone-induced bone resorption does not occur
in the absence of osteopontin. J. Biol. Chem. 276:13065-13071.
- Denhardt, D.T., Burger, E.H., Kazanecki C, Krishna,
S., Semeins, C.M., and Klein-Nulend, J. (2001) Osteopontin-deficient
bone cells are defective in their ability to produce NO in response
to pulsatile fluid flow. Biochem. Biophys. Res. Comm. 288:448-453.
2000
- Ashkar, S., Weber, G.F., Panoutsakopoulou, .V, Sanchirico, M.E.,
Jansson, M., Zawaideh, S., Rittling, S.R., Denhardt, D.T., Glimcher,
M.J., Cantor, H. (2000) Eta‑1 (osteopontin): an early component
of type‑1 (cell‑mediated) immunity. Science 287,
86086‑4.
- Denhardt, D.T. (2000) On the paradoxical ability
of TIMPs either to inhibit or to promote the development and progression
of the malignant phenotype.
In “Inhibitors of Metalloproteinases in Development and
Disease”. Pp 137-151. Edited
by S.P. Hawkes, D.R. Edwards, and R. Khokha.
Harwood Academic Publ. Lausanne, Switzerland.
- Tian, J.T., Sørensen, E.S., Butler. W.T., Lopez,
C.A., Sy, M.-S., and Denhardt, D.T. (2000) Osteopontin and Hyaluronic
Acid Inhibit NO Synthesis by RAW264.7 Cells Stimulated with Inflammatory
Mediators: Collagen Blocks Inhibition by Osteopontin. Cytokine
12:450-457.
- Bonvini, J.M., Schatzmann, U., Beck-Schimmer, B.,
Sun, L.K., Rittling, S.R., Denhardt, D.T., Hir, M.L., and Wuthrich,
R.P. (2000) Lack of an in vivo function of osteopontin in experimental
anti-GBM nephritis. J. Am. Soc. Nephrol. 11:1647-1655.
-
Wu, Y., Denhardt, D.T., and Rittling,
S.R. (2000) Osteopontin expression is required
for full expression of the transformed phenotype by the Ras oncogene.
Brit. J. Cancer. 83:156-173.
1999
-
Yoshitake, H., Rittling, S.R., Denhardt, D.T., Noda,
M. (1999) Osteopontin-deficient mice are resistant to ovariectomy-induced
bone resorption. Proc. Natl. Acad. Sci. (US) 96:8156-8160.
-
Rittling, S.R., and Denhardt, D.T. (1999) Osteopontin
function in pathology: Lessons from osteopontin-deficient mice.
Exptl. Nephrology 7:103-113.
1998
-
Rittling, S.R., Matsumoto, H.N., McKee, M.D., Nanci,
A., An, X.-R., Novick, K., Kowalski, A., Noda, M., and Denhardt,
D.T. (1998) Mice lacking osteopontin show normal development and
bone structure but display altered osteoclast formation in vitro.
Journal Bone Mineral Research 13:1101-1111.
-
Rajan, S.S. Lackland, H., Stein, S., and Denhardt, D.T.
(1998) Presence of an N-terminal polyhistidine tag facilitates stable
expression of an otherwise unstable N-terminal domain of mouse tissue
inhibitor of metalloproteinase-1 in E. coli. Protein
Expression and Purification 13:67-72 .
-
Rajan, S.S., Denhardt, D.T., Lackland, H., and Ludescher,
R.D. (1998) Analysis of the conformational stability of the active
domain of recombinant mouse TIMP-1 by intrinsic fluorescence. Biochem.
Biophys. Res. Comm. 242:303-309.
1996
-
Rollo, E.E., Laskin, D.L., and Denhardt, D.T. (J. Leukocyte
Biology 60, 397-404, 1996)Osteopontin inhibits nitric oxide production
and cytotoxicity by activated RAW264.7 macrophages
-
Rollo, E.E., and Denhardt, D.T. (1996) Differential
Effects of Osteopontin on the Cytotoxic Activity of Macrophages
from Young and Old Mice. Immunology 88:642-647.
-
Walther, S.E., and Denhardt, D.T. (Cell Growth and Differentiation,
7, 1579-1588, 1996). Directed Mutagenesis Reveals that Two Histidines
in Tissue Inhibitor of Metalloproteinase-are Each Essential for
the Suppression of Cell Migration, Invasion and Tumorigenicity
-
Malyankar, U.M., Rittling, S.R., and Denhardt, D.T.
(1996) Generation of Stable Mitogen Regulated Protein/Proliferin
mRNA in Mouse Embryo Fibroblasts Transiently Transfected with Genomic
Clones. J. Cellular Biochemistry 60:198-210.
1995
- Feng, B., Rollo, E.E., and Denhardt, D.T. (1995) Osteopontin (OPN)
may Facilitate Metastasis by Protecting Cells from Macrophage NO-mediated
Cytotoxicity: Evidence from Cell Lines Down-regulated for OPN Expression
by a Targeted Ribozyme. Clin. Exptl. Metastasis 13:453-462.
- Lopez, C.A., Olson, E.S., Adams, J.C., Mou, K., Denhardt, D.T.,
and Davis, R.L. (1995) Osteopontin Expression Detected in Adult Cochlea
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